Keywords

Cell Cycle Proteins; DNA Methylation; Embryonic Development; Embryonic Stem Cells; Epigenomics

Research group(s)

• Epigenetic Reprogramming in the Wossidlo lab
  Head: Mark Wossidlo
  Research Area: We are interested in the embryo intrinsic epigenetic reprogramming that drives early preimplantation development and the establishment of cellular potency.
  Members:
  Kristeli Eleftheriou
  Mark Wossidlo
  Julia Arand

Selected publications

1. Arand, J. et al., 2021. Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation. EMBO reports. Available at: http://dx.doi.org/10.15252/embr.202153968.
2. Doan, A. et al., 2021. RB depletion is required for the continuous growth of tumors initiated by loss of RB B. E. Clurman, ed. PLOS Genetics, 17(12), p.e1009941. Available at: http://dx.doi.org/10.1371/journal.pgen.1009941.
3. Arand, J., Reijo Pera, R.A. & Wossidlo, M., 2021. Reprogramming of DNA methylation is linked to successful human preimplantation development. Histochemistry and Cell Biology, 156(3), pp.197–207. Available at: http://dx.doi.org/10.1007/s00418-021-02008-6.
4. Arand, J. et al., 2015. Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo. Epigenetics & Chromatin, 8(1). Available at: http://dx.doi.org/10.1186/1756-8935-8-1.
5. Arand, J. et al., 2012. In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases D. Schübeler, ed. PLoS Genetics, 8(6), p.e1002750. Available at: http://dx.doi.org/10.1371/journal.pgen.1002750.