Abteilung für Anatomie - Jobs
Ausbildungsstellen zum Fachärztin/Facharzt für Anatomie
An der Abteilung für Anatomie werden Fachärztinnen und Fachärzte für Anatomie ausgebildet (www.aerztekammer.at).
Die tägliche Routine besteht aus Körperspendebegutachtung, der Planung, Koordination und Abhaltung von prae- und postgraduellen Lehrveranstaltungen, der Bearbeitung wissenschaftlicher Fragestellungen und der Durchführung angeleiteter und selbstständiger Forschungsprojekte. Die Ausbildung eine Basisausbildung kann, muss aber nicht absolviert werden.
Bewerbungen um Ausbildungsstellen bitte gerne als Initiativbewerbungen an die Abteilungsleitung.
Wissenschaftliche/r Projektmitarbeiter/in
Die wissenschaftliche Aussrichtung der Abteilung und ihre zentralen wissenschaftlichen Projekte ist aus der Ausrichtung der Research Areas und den rezenten Publikationen der Abteilungsmitarbeiter/innen ableitbar.
Personen, die über einen akademischen Abschluss in einem naturwissenschaftlichen oder technischen Studium verfügen, über einen exzellenten Track-Record verfügen und Interesse an der Mitarbeit an Projekten der Abteilung haben bitten wir Initiativbewerbungen an die Abteilungsleitung zu richten.
Abteilung für Zellbiologie - Jobs
Part-time (20hrs) support position to the scientific coordination of a special research program on RNA modifications
The SFB 80 RNA-DECO (www.rna-deco.org) is looking for a part-time support to coordinate thespecial research program on RNA modifications. The coordination position will:
· Coordinate joint activities of 12 research groups from the Vienna
and Innsbruck areas
· organize retreats and seminars with the participating research
groups
· organize scientific meetings
· administer and optimize internal and external communication
· maintain the web page and other outreach activities
· help with advertising and hiring personnel
· organize the purchasing of research equipment
· administer the project reporting and follow-up application
The qualified person should be trained in the sciences (Masters or PhD), be fluent in English (written and spoken) and have proficient communication skills in German. Administrational skills are required.
Salary will be according to your qualifications following FWF schemes (a combination with lab-related work is possible)
The position is located at the Center of Anatomy & Cell Biology of the Medical University of Vienna (1090 Vienna).
The position is open immediately and runs until March 2024 with the option of a four-year extension.
If interested please contact: Greeshma.Manjaly@meduniwien and Michael.Jantsch@meduniwien.ac.at no later than May 15th.
PhD position on RNA modifications and innate immune sensing in the Lab of Michael Jantsch, Medical University of Vienna
An EU-funded PhD position is available in the lab of Michael Jantsch. The international training network (ITN) consists of a multinational team studying RNA modifications in a multidisciplinary approach. Secondments allow diverse training and research experiences at a competitive salary including family allowance.
The lab of Michael Jantsch studies adenosine deamination in mice which is one of the most abundant RNA modifications in mammals. Deamination of adenosines (A) leads to the formation of inosines (I). Inosines are interpreted as guanosines by most cellular machineries, including translation.
A to I editing is mediated by two enzymes, ADAR1 or ADAR2. While ADAR2 is mainly responsible for editing events that alter the coding of mRNAs or the function of small RNAs, ADAR1 acts as an antiviral protein. Interestingly, loss of ADAR1 leads to elevated interferon signaling and upregulation of the antiviral signals.
It will be the aim of this PhD project to decipher the signals that trigger antiviral responses and to determine how the introduction of inosines prevents antiviral signaling (Fig 1).
The Division of Cell & Developmental Biology provides a stimulating atmosphere for RNA research with five research groups working on RNA modifications. The team is tightly linked to other Austrian RNA researchers via an RNA research network. The Division of Cell & Developmental Biology is located near the center of historic Vienna.
Interested candidates please send their application including a curriculum vitae, a letter of motivation and two contacts for references to
Michael.Jantsch@meduniwien.ac.at under the reference "ROPES"
until March 30th 2021
For further information please visit:
ROPES: https://cordis.europa.eu/project/id/956810/de
https://www.rna-deco.org/
https://anatomieundzellbiologie.meduniwien.ac.at/group-jantsch
Post Doctoral Position in RNA-Biology
Impact of Filamin RNA-editing on mouse organ homeostasis
A 2-year post doctoral position is available in the Lab of Michael Jantsch, Medical University of Vienna from February 2021.
Research Background: Adenosine deamination by ADARs converts adenosines to inosines in structured regions of RNA. Inosines are recognized as guanosines during translation therefore leading to mRNA recoding. Editing of the Filamin mRNA leads to a Glu to Arg exchange in the highly interactive repeat 22 region of the protein.
Editing occurs in the mRNAs encoding Filamin A and Filamin B at the same position. To study the impact of these conserved editing events we have generated mice deficient in Filamin A or Filamin B editing, but also mice expressing constitutively edited Filamin A or Filamin B. So far, we could show that lack of Filamin A editing affects blood pressure control. Current work indicates that Filamin A editing also affects vascularization and tumor growth.
The project: In this FWF funded project, we aim to identify cellular pathways that are affected by Filamin A and Filamin B editing and will determine the interactome of the edited and unedited versions of these proteins. We also aim to determine the impact of altered Filamin B editing on mouse physiology.
Your profile: Background in Biochemistry or Biology, Experience in Cell Biology, RNA Biology, or work with mouse models.
If interested, send your CV and motivation letter to Michael.Jantsch@meduniwien.ac.at by Jan 15th 2021.
Background info:
DOI: 10.15252/embj.
DOI: 10.1080/15476286.2018.1480252
MASTER THESIS IN STRUCTURAL BIOLOGY
DJINOVIC & JANTSCH LABs
Understanding the consequences of RNA-editing at the structural level
The Djinovic Lab uses a combination of biochemical, biophysical and structural biology approaches, the Jantsch Lab uses biochemistry and mouse models to understand the impact of RNA-editing at the cellular and organismic level
The labs of Kristina Djinovic-Carugo and Michael Jantsch are teaming up to understand how RNA-editing induced recoding of the pre-mRNA encoding the actin crosslinking protein filamin A changes the structure of this protein. To achieve this, the protein structure of parts of the filamin A protein will be determined in their natural and "edited" state.
Background: Adenosine deaminases acting on RNA deaminate adenosines to inosines in structured regions of RNAs. The RNA-editing process occurs in millions of sites in the human transcriptome. As inosines are interpreted as guanosines during translation, this RNA-editing process can alter codons and therefore lead to the formation of proteins that are not encoded in the genome. A prominent adenosine to inosine deamination event is found in the mRNA encoding filamin A, an abundant actin crosslinking protein that links the cellular cortex and transmembrane proteins with the cytoskeleton. Changes in the editing pattern of the filamin A mRNA lead to the expression of altered filamin A which causes high blood pressure but also causes gastrointestinal inflammatory disorders. To understand the molecular consequences of the editing-induced amino acid exchange, the affected domain will be studied by structural and biophysical means.
Thesis description: We are looking for a highly motivated and dedicated student to use a combination of structural and molecular biophysics approaches to investigate the molecular consequences of RNA-editing of filamin A. The successful candidate will have the opportunity to (i) express and purify native and “edited” variants and perform a comparative molecular biophysics analysis (ii) X-ray crystallography to determine their structures at high resolution (iii) use biochemical and biophysical methods to validate the mechanistic model.
Requirements: background in biochemistry or molecular biology, studies of Molecular Biology, Biochemistry, Chemistry, Cell Biology or related fields.
Application Details: Interested students, please send
- A cover letter
- Your CV
- Contact details of two referees
To Michael Jantsch <michael.jantsch@meduniwien.ac.at> and
Kristina Djinovic-Carugo <Kristina.Djinovic@univie.ac.at>
Duration of thesis: 12 months, salary: 440 € per month. Beginning: immediately.
Further Information:
https://www.maxperutzlabs.ac.at/research/research-groups/djinovic
Relevant publications:
DOI: 10.15252/embj.201694813
DOI: 10.1080/15476286.2018.1480252
Schnellinfo
Featured
